Easton has made appearances on television shows such as Ally McBeal and The Practice. He had a recurring role on the science fiction television series Mutant X. He played the dual lead role in the 1996 thriller series Two, as well as starring roles in two science fiction series: VR.5 and Total Recall 2070.
Additionally, Easton has appeared on soap operas, first starting out in the role of Tanner Scofield on NBC's Days of Our Lives from 1991 to 1992. He went on to a two-year stint as vampire Caleb Morley on Port Charles from 2001 until its cancellation in 2003. Easton portrayed John McBain on the ABC soap opera One Life to Live from October 2003 until the series ended in January 2012.
Easton, with other One Life to Live actors, such as Roger Howarth, Kristen Alderson, Kassie DePaiva and Florencia Lozano, appeared on sister soap opera General Hospital. Easton reprised his One Life to Live role of John McBain from March 2012 - March 2013 and his Port Charles/General Hospital role of Caleb Morley from February to March 2013. Easton exited his General Hospital roles due to legal issues regarding Prospect Park's revival of One Life to Live. Easton was slated to return to General Hospital at some point, possibly in a new role. Prospect Park currently owns the rights to all One Life to Live characters; TV Guide reported that because ABC does not want to risk any further legal disputes with Prospect Park concerning the characters, the only way to avoid such disputes may be to have the former One Life to Live actors portray "characters that in no way resemble the current ones" in order to stay on General Hospital. Easton returned to General Hospital in May 2013 as Dr. Silas Clay. On July 29, 2015, it was confirmed that Easton would exit General Hospital.
A collection of Easton's poetry was published under the title Eighteen Straight Whiskeys. He is the author of the Soul Stealer series of graphic novels, drawn by Christopher Shy, as well as several currently unproduced screenplays. He collaborated with author Peter Straub on the graphic novel The Green Woman, which featured art by John Bolton and was published by Vertigo Comics in 2010. Easton and Straub met and became friends after the latter, a fan of daytime soap operas, visited the set of One Life to Live. Easton released the graphic novel Credence on November 1, 2013. On February 2, 2016, it was announced that Easton would return to General Hospital. His first airdate was to be March 18, 2016. It was pushed back due to ABC airing the funeral of former First Lady Nancy Reagan. His new character was revealed on Friday, March 19, 2016. as Hamilton Finn.